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BioSentinel offers an extensive line of products for your botulinum neurotoxin (BoNT) detection needs. Whether determining the potency of BoNT pharmaceuticals, screening and characterizing BoNT inhibitors, or quantifying BoNT concentrations in food and environmental samples, BioSentinel’s assays have sensitivity levels equivalent or better than the mouse LD50 assay.Our fluorescent mix and read assays can be used in high throughput formats and are able to detect multiple BoNT serotypes in a wide range of complex matrices.BioSentinel’s BoNT detection assays are the new standard for quantifying pharmaceutical BoNT preparations.

For additional information or assistance in selecting the right product for your application, please contact customer support at 1-866-807-0324 or info@biosentinelpharma.com.

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BoTest® Botulinum Neurotoxin Detection Kits. These flexible assays provide real-time detection of BoNT proteolytic activity in an optimized reaction buffer. Intended uses include quantification and characterization of BoNT pharmaceutical preparations,drug discovery, high throughput screening applications,and real-time detection applications. We offer two kits that cover detection of six of the seven BoNT serotypes.

A1004 BoTest® A/E BoNT Detection Kit, 200 assays.

For the detection and quantification of BoNT serotypes A and E.

A1009 BoTest® B/D/F/G BoNT Detection Kit, 200 assays.

For the detection and quantification of BoNT serotypes B, D, F, and G.

A1039 BoTest® KO

Non-specific Protease Assay Kit. The BoTest® KO Kit can be used to control for false positives or to optimize assay conditions for samples that contain non-specific protease activity.

BoTest® Matrix Botulinum Neurotoxin Detection Kits. These serotype-specific assays are robust and sensitive tools for the detection and quantification of BoNT proteolytic activity contained in complex matrices such as pharmaceutical preparations, food samples, blood, and serum, These kits are sold as a combination of a serotype-specific Matrix BoNT Immunoprecipitation Kit and theappropriate BoTest® BoNT Detection Kit.

A1015 BoTest® Matrix A BoNT Detection Kit, 200 assays.

A combination kit containing both the BoTest® A/E BoNT Detection Kit and the Matrix A Immunoprecipitation Kit. It is specific for the detection and quantification of BoNT serotype A (BoNT/A)

A1023 BoTest® Matrix B BoNT Detection Kit, 200 assays.

A combination kit containing both the BoTest® B/D/F/G BoNT Detection Kit and the Matrix B Immunoprecipitation Kit. It is specific for the detection and quantification of BoNT serotype B (BoNT/B)

A1019 BoTest® Matrix E BoNT Detection Kit, 200 assays.

A combination kit containing both the BoTest® A/E BoNT Detection Kit and the Matrix E Immunoprecipitation Kit. It is specific for the detection and quantification of BoNT serotype E (BoNT/E)

A1026 BoTest® Matrix F BoNT Detection Kit, 200 assays.

A combination kit containing both the BoTest® B/D/F/G BoNT Detection Kit and the Matrix F Immunoprecipitation Kit. It is specific for the detection and quantification of BoNT serotype F (BoNT/F)

Matrix Botulinum Neurotoxin Immunoprecipitation (IP) Kits.The BoNT Immunoprecipitation Kits can be purchased separately to immunoprecipitate, concentrate, and purify BoNT out of a variety of solutions including foods, culture supernatants, serum, and drug substances for user-defined analysis. For the actual quantification of bound BoNT, we recommend the BoTest® BoNT Detection Kits described above.

A1014 Matrix A BoNT Immunoprecipitation Kit, 200 assays.

This kit uses an anti-BoNT/A antibody conjugated to magnetic beads.

A1018 Matrix E BoNT Immunoprecipitation Kit, 200 assays.

This kit uses an anti-BoNT/E antibody conjugated to magnetic beads.

A1022 Matrix B BoNT Immunoprecipitation Kit, 200 assays.

This kit uses an anti-BoNT/B antibody conjugated to magnetic beads.

A1025 Matrix F BoNT Immunoprecipitation Kit, 200 assays.

This kit uses an anti-BoNT/F antibody conjugated to magnetic beads.

BoLISA® Botulinum Neurotoxin Sandwich ELISA Detection Assays.

Used to detect and quantify total BoNT mass from liquid matrices using a traditional sandwich ELISA approach.

A1029 BoLISA® A BoNT Sandwich ELISA Detection Kit, 100 assays.

Uses an anti-BoNT/A capture antibody and a biotinylated anti-BoNT/A detection antibody.

A1045 BoLISA® B BoNT Sandwich ELISA Detection Kit, 100 assays. Uses an anti-BoNT/B capture antibody and a biotinylated anti-BoNT/B detection antibody. 

A1042 BoLISA® C BoNT Sandwich ELISA Detection Kit, 100 assays. Uses an anti-BoNT/C capture antibody and a biotinylated anti-BoNT/C detection antibody.  

A1034 BoLISA® E BoNT Sandwich ELISA Detection Kit, 100 assays.

Uses an anti-BoNT/E capture antibody and a biotinylated anti-BoNT/E detection antibody. 

BoTest® Drug Screening Services for discovery of BoNT antagonists BioSentinel can screen drug libraries of nearly any size using our BoTest Kits. Please inquire for more information.

Note: Botulinum toxin is not supplied with any BioSentinel products. For Research Use Only: not for use in diagnostic procedures. BoTest® is a trademark of BioSentinel, Inc.